Published on December 7, 2018 | Updated on January 29, 2019

CORTEX conference by Pierre Savatier

December 6th, 2012

Genome modification in non human primates: toward the generation of monkey models of human diseases

 We explore the mechanisms of self-renewal and pluripotency using embryonic stem cells from several mammalian sepcies. In particular, we explore ground state pluripotency in the rabbit and primate pre-implantation embryos. Our goal is to create rabbit and macaque ES cells capable of colonizing the developing embryo, suitable for the generation of chimaeras. Another aspect of our work focuses on the regulation of the cell cycle, which shows unusual characteristics in pluripotent stem cells.